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Cohen Veterans Bioscience

   ADVANCING BRAIN HEALTH

The Circuit
Quarterly Brain Health News - June 2022

An Important Message From CEO & President Dr. Magali Haas

Dear Friends and Colleagues, 

“Doing science right requires doing the right science.”

Last week, Dave DeMarco, PhD, offered this succinct quote about our approach when asked why he chose to join our board of directors and further our mission. This philosophy set the foundation for our June 2022 company-wide meeting as our team came together in Lake George, NY to brainstorm and strategize for the months and years ahead. 

Team MeetingIn addition to the board’s participation, we were honored to hear from Frank Larkin, Chair of our Veterans Advisory Council, and 22 Jumps founder Tristan Wimmer about the most urgent challenges Veterans face today. Their moving comments imbued all of us with a deepened sense of purpose.   

In this newsletter, you’ll learn more about new and exciting initiatives we’re pursuing to advance “the right science.” 

We just launched a free training video series to help preclinical researchers navigate the NIH’s 2015 policy on incorporating sex as a biological variable into research. These videos, developed by our Senior Director of External Affairs Chantelle Ferland-Beckham, PhD are part of our ongoing efforts to advance best practices in preclinical research. Prior to 2015, most biomedical research was conducted solely in male animals. We’re proud to offer this valuable educational resource that will help the next generation of researchers drive discoveries that benefit everyone.

Over the past several years, psychedelics have emerged as a possible solution for treatment-resistant PTSD and other brain disorders. We’re committed to examining psychedelics as a class of therapeutics because of their potential as effective treatments. In May, our Chief Medical Officer Dr. Allyson Gage spoke at the Psychedelic Therapeutics and Drug Development Conference. She identified the need for biomarkers predictive of treatment response and raised key questions we need to answer regarding this novel category of potential therapeutics.

The need for tailored treatments is echoed below in an interview with former police officer Christian Nielsen, who overcame PTSD, but not without the difficult trial and error of finding the treatment solutions that worked best for him.

Our goal is to advance tailored treatments for PTSD so that a clinician can target the right treatment to the right person at the time when they need help most. 

We remain committed to “doing science right” to lead us there.

Strength and Honor,


Magali Haas, MD, PhD
Magali Haas, MD, PhD
CEO & President
Cohen Veterans Bioscience

Sex as a Biological Variable in Preclinical Research
Sex in Science Video Series to Strengthen Basic Research

New 18-part video program focuses on sex as a biological variable in preclinical research to address knowledge gaps in scientific inquiry and accuracy

Cohen Veterans Bioscience is proud to introduce an unprecedented new video series that provides the practical knowledge necessary for researchers to incorporate sex as a biological variable into their current and future research. Titled Addressing Sex as a Biological Variable in Preclinical Pharmacology and Neuroscience Research: Accounting for Neglected Factors and Applying Practical Solutions to Enhance Rigor and Reproducibility, the 18-part video training program was developed to help strengthen the translation of basic research findings to human care.

Quote from Dr. Ferland-BeckhamDeveloped under the leadership of Dr. Chantelle Ferland-Beckham, PhD, Senior Director of External Affairs and head of educational programming for CVB, the video series was created in response to a 2015 National Institutes of Health (NIH) policy aiming to transform research design, analysis, and reporting in the preclinical sphere by ensuring that both male and female organisms were included in early-stage animal research. A similar policy was enacted nearly 20 years earlier (in 1993) mandating the inclusion of women in human studies. 

Learn More
 
PTSD Awareness Month
June is Post-Traumatic Stress Disorder (PTSD) Awareness Month

CVB is driving progress to advance precision solutions for PTSD

To improve the quality of life of people suffering from PTSD, we’re working to identify the biological mechanisms underlying the condition. Objective diagnostic tools would allow clinicians to predict the likelihood that a given patient would respond to a given therapeutic, enabling personalized medicine for people living with PTSD.

Learn more about our research

Ryan Larkin, Navy SEAL
Memorial RockN’4Ryan rockfish tournament reels in funds for traumatic brain injury

By Meghan Rodgers, contributing writer

The first annual RockN’4Ryan Rockfish Tournament brought together employees from leading companies in Maryland’s technology industry last month to raise awareness for traumatic brain injuries (TBI) and veteran suicide.

The event was held May 5, 2022, in honor of Ryan Larkin, a decorated Navy SEAL who served four tours of duty during more than a decade of service. During his deployments, Larkin saw heavy combat that required breaching through walls and doors with powerful explosions.

His service also exposed him to improvised explosive devices, known as IEDs.

As a result, Larkin experienced headaches, insomnia, trouble concentrating and irritability. Friends noted a sharp change in behavior. Despite seeking help from the medical community for several years, his condition went without an accurate diagnosis. In 2017, Larkin ended his own life.

Continue Reading


Quote from Christian NielsenWatch the Interview: A former police officer discusses overcoming PTSD

We’re thrilled to have spoken with Christian Nielsen, a former police officer who suffered from work-related PTSD after nearly a decade of police work in Denmark. After his battle with PTSD, Christian joined the Danish Naval Special Warfare group where he worked as a contractor and a commercial diver for six years.

We spoke with him about the challenges he faced, what approaches worked best for him, and what he hopes for the future of PTSD diagnosis and care.

Watch the Video Interview

Video: A Conversation with the BASE Jumpers & Speakers of 22 Jumps Idaho

Hear personal stories from Veterans, clinicians and researchers raising awareness of the need for better solutions for traumatic brain injury and post traumatic stress to reduce the incidence of suicide.

Learn about how organizations are collaborating and advocating to bring new solutions to Veterans and others who have sustained brain trauma.

Moderator: John Greenway, President of Mission2Alpha

Participants and Veterans:

  • Tristan Wimmer, Marine Veteran & Scout Sniper, Founder of 22 Jumps – Read Tristan’s Story
  • Nick Cliche, US Air Force – Read Nick’s Story
  • Andrew Katz, US Army
  • Mark Zervas, PhD, Deputy Director, Translational Research & Development, CVB
  • Mahmoud Ghannoum, PhD
  • Eric Johnson, MD

22 Jumps in Twin Falls, Idaho Raises More Than $20,000 for Research

Three BASE jumpers from the Army, Air Force, and Department of Veterans Affairs each succeeded in completing 22 BASE jumps in a single day in honor of the 22 Veterans and service members who lose their battle to suicide each day.

BASE jumpers Andrew Katz (US Army), Brittany Cantwell (Dept. of Veterans Affairs) and Nick Cliche (Air Force) helped to raise more than $20,000 for traumatic brain injury (TBI) research. TBI is a major risk factor for suicide.


Recent Advocacy Updates
  • The VA announced the launch of the Scott Hannon Initiative for Precision Mental Health to drive biomarker research focused on mental health conditions, promote data sharing, and speed the translation of research findings to care for Veterans. We're proud to have advocated for this important step toward precision medicine for Veterans' health.
     
  • We recently joined more than 100 research, academic and nonprofit organizations in a letter organized by Research America urging the Senate to ensure robust funding for research to meet the very real challenges of brain disorders.
     
  • The Senate advanced the Honoring Our PACT Act of 2021, which expands healthcare and benefits coverage for Veterans exposed to toxic chemical and burn pits. CVB was proud to add our voice to advocate for this important bill, particularly section 508, which requires a study on the possible relationship between toxic exposures and mental health outcomes such as TBI and PTSD.
News From Our Team
Chief Medical Officer Dr. Allyson Gage Presents at The 2nd Annual Psychedelic Therapeutics & Drug Development Conference

Dr. Allyson GageIn her presentation, Dr. Gage highlighted the multiple pharmacologic targets of psychedelic compounds. She reviewed the hurdles for scalability of psychedelics as therapeutics and provided an overview of the known unknowns with this novel category of potential therapeutics, including whether the psychedelic experience is needed for the therapeutic effect.

Dr. Gage also discussed the need for biomarkers of different types to accelerate the clinical development of these compounds, including biomarkers of therapeutic effect for trial endpoints and demonstration of clinical effect, identifying patient sub-populations, treatment response and more. Click here to watch a video of Dr. Gage's presentation.

CVB Sponsors Lunch Symposium at Neurotrauma 2022

Neurotrauma 2022 Lunch SymposiumCohen Veterans Bioscience recently sponsored a lunch symposium at Neurotrauma 2022 focused on the Brain Trauma Blueprint—a roadmap to advance solutions for TBI.

Our CEO & President Dr. Magali Haas spoke about a new Public-Private Partnership Coalition being established to support the execution of this new roadmap.

CVB Attends 12th Annual Traumatic Brain Injury Conference

Dr. Magali Haas at the TBI ConferenceOur CEO & President Dr. Magali Haas and Executive Director of the BRAINCommons Dr. Maryan Zirkle recently attended the Traumatic Brain Injury Conference to discuss ground-breaking research and ways to improve TBI care.

Dr. Haas spoke about our roadmap approach in her presentation, "The PTSD Research Roadmap: A Model Approach for Discovering New Treatment Opportunities for Traumatic Brain Injury".

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