View this email in your browser
Cohen Veterans Bioscience

   ADVANCING BRAIN HEALTH

The Circuit
Quarterly Brain Health News - September 2021

An Important Message From CEO & President Dr. Magali Haas

Dear Friends and Colleagues, 

I wanted to share this quarter a personal story that, for far too many of us, is a common occurrence, and tragically, not surprising. A member of my team saw that her son away at college was calling, so she turned her attention to Venmo. Only unlike the usual outreach, it wasn’t money that he wanted. He just needed his mother.

Her son was so distraught that he was completely inaudible. She said that for those few minutes, the sheer terror of trying to understand what happened to him or upset him so profoundly was paralyzing. On FaceTime she could at least surmise that he didn’t appear sick and he was alive.

But sadly, his best friend was not. Twenty-year-old Will took his life the night before. And as too often the case, no one saw it coming. He was popular—the president of his fraternity—and described as selfless and someone who all looked up to. He “cherished family, chivalry, and service more than anything.” So with so much going for him, what could possibly drive this young man to impulsively take his life? 

Of course, we cannot compare my team member’s experience to the living hell that Will’s parents are going through now. But no parent, friend, or family member should ever receive a call like that. How many more people of all walks of life and ages do we have to lose before we make progress in better suicide prevention?

This is a complex issue, and there are currently no easy solutions. Still, we could at least be doing a better job tackling and supporting research to better predict who may be at greatest risk for suicide to inform prevention.  

What biological factors might increase risk for suicide? Both depression and suicidal behavior have been linked to decreased serotonin in the brain. One of the goals of understanding the biology of suicidal behavior is to improve treatments. Research has also shown that PTSD and TBI are risk factors for suicidality.

In that same vein and to recognize Suicide Awareness Month, I wanted to highlight in this issue an article by our highly decorated Frank Larkin, 40th U.S. Senate Sergeant at Arms and Chair of the Cohen Veterans Bioscience Veterans Advisory Council. It is one of the most compelling pieces I’ve ever read. It’s Frank’s story, and all began on 911. We thank Frank for all that he does and his boundless contributions to raising awareness.

Also, we continue to be grateful to all the families, while having experienced deep loss, generously give their time to advocacy and building awareness.

We hope that through our newsletter, you will see the progress we are making to advance research in brain trauma and build platforms that transform the research ecosystem across brain disease with the goal that no other family ever experiences this type of loss.

Be happy, stay well, and be safe.


Magali Haas, MD, PhD
Magali Haas, MD, PhD
CEO & President
Cohen Veterans Bioscience

Frank Larkin in New York City after 9/11
Reflections On The Impact of 9/11 From a Secret Service Agent Who Was There – And Whose Family Was Forever Changed

By Frank Larkin, Chair of the Veterans Advisory Council

On Sept. 11, 2001, I was a U.S. Secret Service senior supervisor/special agent assigned to our New York Field Office located in Building #7 of the New York City World Trade Center (WTC) complex.

On that day, I was following my daily routine coming into the office around 6am to jog along the Hudson River. It was a beautiful, cloudless, crystal blue day with a gentle wind blowing. As I ran back toward the World Trade Center complex, I remember remarking to myself how beautiful the twin towers looked and even thought how lucky we had been that nothing had happened to us considering all the conflicts popping up around the globe.

I guess I was reflecting on the first World Trade Center bombing on Feb. 26, 1993, that seriously damaged our New York Field Office. At the time, our office was in WTC#6. I had responded to New York City from Washington, DC, following the explosion with equipment and other personnel to assist the office with recovery operations. Several of our agents had been injured in that attack.

I got back to the office after my run and was coming out of the shower when the building shook and the lights flickered. A few seconds later an announcement over the speaker system alerted us that there had been a massive explosion in WTC#1 and we were to immediately evacuate the building.

Continue Reading

Team Science in Action
Quote from Dr. Andreas Jeromin
Cross-Platform Evaluation of Commercial Metabolomics Platforms to Support Precision Therapeutics Research

Standardization of diagnostic tools could lead to more targeted treatments across neuropsychiatric disorders

As part of its RAPID-Dx (Research Alliance for Precision Therapeutics, Innovation and Diagnostics) program, researchers from Cohen Veterans Bioscience (CVB) and collaborators conducted a blinded cross-platform analysis (or “bakeoff”) of commercially available assay platforms to inform selection in the conduct of neuropsychiatric biomarker research.

The findings, published online September 8th in Metabolites [DOI: 10.3390/metabo11090609], investigate coverage across metabolite classes and relative accuracy and precision of the platforms. The study also evaluated the specific utility of these metabolomic platforms for analysis of metabolites implicated in post-traumatic stress disorder (PTSD) research.

CVB led the research in collaboration with other prominent metabolomics experts.

Learn More
Quote from Dr. Jamshid Ghajar
Cohen Veterans Bioscience, Stanford Brain Performance Center, and Brain Trauma Foundation Join Forces to Advance Precision Medicine for TBI

Cohen Veterans Bioscience, Stanford Brain Performance Center, and the Brain Trauma Foundation announced a collaboration aimed at transforming the treatment recommendations and guidelines for mild traumatic brain injury (TBI) (inclusive of concussion) and advancing the field more broadly toward a precision medicine approach.

Bringing together expertise in data science, patient care, and guideline development, the three organizations aim to reframe the classification of mild TBI using an evidence-based patient categorization, with the ultimate goal of bringing forth new treatment strategies and guidelines.

Learn More

Quote from Dr. Douglas H. Smith
Traumatic Brain Injury: Advancing Preclinical Science

Cohen Veterans Bioscience Publishes Recommendations for the Advancement of Preclinical Science in Traumatic Brain Injury

Published in the Journal of Neurotrauma on July 1, 2021 [DOI: 10.1089/neu.2021.0094], the article is titled “Roadmap for Advancing Preclinical Science in Traumatic Brain Injury.” The coauthored review discusses the state of preclinical research in traumatic brain injury (TBI), how preclinical models contribute to the success and failure of clinical solutions for TBI, and considerations for their improvement to aid translational science.

Learn More
From genetics to systems biology of stress-related mental disorders

A review of genetic studies, co-authored by CVB’s Chief Information Officer Dr. Lee Lancashire, suggests an overlap across PTSD, major depressive disorder, and anxiety disorders.

Published in Neurobiology of Stress, the paper also provides an overview of systems biology and other multi-omic approaches that, together with advanced machine learning and AI, we expect will advance the detection, understanding and prediction of mental disorders.

Learn More
 
News From Our Team
Eugene Rakhmatulin
Q&A with Eugene Rakhmatulin on Challenges & Opportunities in Brain Health Research

Chief Technology Officer Eugene Rakhmatulin has launched a new department at Cohen Veterans Bioscience (CVB) dedicated to developing solutions to manage complex data collection, integration, and analysis. He has more than two decades of experience in information technologies, including more than 15 years in the life sciences industry.

We spoke to Eugene about his innovative work at CVB, what’s ahead in the future of technology, and what it means for the brain research field.

What technological advancements are revolutionizing brain health today?

Access to large and diverse datasets and decreasing computing and storage costs in combination with machine learning advancements allows scientists to come up with and validate their hypothesis in-silico faster than ever. Wearable sensors, including many consumer-level devices, enable the collection of continuous streams of data outside of the lab environment.


Continue Reading
Recent & Upcoming Events
Brain Health Nexus
Brain Health Nexus - Envisioning and Launching a Scientific and Technology Roadmap to Drive Tomorrow's Interventions and Cures

Regretfully, due to the Covid-19 Delta variant and the limits to international travel, we have decided to move the Brain Health Nexus event (previously scheduled for October 2021) to early next year on February 8th & 9th.

We apologize for this inconvenience, but our first and foremost concern is the health and safety of our participants.

The growing mental health consequences of the pandemic have highlighted a need for a renewed emphasis on brain health. The Brain Health Nexus will convene more than 200 global thought leaders across the brain health ecosystem, including experts from research organizations and other non-profits, finance, government, technology, patient advocacy groups, industry, and healthcare, to design and launch a science and technology roadmap for collective action to combat the growing global burden of brain disease.

This is an invitation-only event, contact us for more information. 

Sponsorship opportunities are available now.

Learn more about Brain Health Nexus

Steering Committee
Speakers
Video: A Conversation with Veteran BASE Jumpers of 22 Jumps

Parachuting with Purpose: The Lived Experiences of Veterans with Invisible Wounds

Hear personal stories from Veterans raising awareness of the need for better solutions for traumatic brain injury and post traumatic stress to reduce the incidence of suicide.

The “invisible wounds of war” are not so invisible: The high rates of suicide and other maladies gripping our nation’s military families are right in front of us.

As people experience brain trauma differently, the field has been stymied by a one-size-fits-all approach and lack of objective tools and treatments to effectively diagnose and manage TBI and post-traumatic stress disorder (PTSD). TBI and PTSD are risk factors of suicide. Learn about how organizations are collaborating and advocating to bring new solutions to Veterans and others who have sustained brain trauma.

Learn More & Register to View the Video
Running to raise funds for PTSD research

Tyler Guerriero, an Air Force reservist and Marine Veteran, has served our country for the past twelve years. To support CVB’s PTSD research, Tyler is running Denver’s Colfax Marathon on October 16, 2021 to raise awareness that PTSD can be a risk factor for suicide.

Tyler is advocating for new research and expanded PTSD treatment options to help the many active duty members of the armed forces and Veterans who are suffering. Tyler was inspired to advocate for the cause after seeing a former business school classmate, Tristan Wimmer, and his 22 Jumps fundraising efforts.

If you are in the Denver area, cheer on Tyler in his first marathon on October 16th!

Learn More

How to Host a Fundraiser
Join the fight to fast-track personalized diagnostics and treatments for all people suffering from brain injury or brain disorders

Across the country, Veterans, first responders, and everyday heroes are using their hobbies and passions to help fund our translational research, which could be transformative.

Learn how to channel your passion or hobby into accelerating solutions for brain disorders.

How to Host a Fundraiser

Suicide Prevention Awareness
September is Suicide Prevention Awareness Month

Understanding How Suicide Relates to Post-Traumatic Stress Disorder and Traumatic Brain Injury

Every year, more than 41,000 people die by suicide. Beyond Suicide Awareness Month, let's help combat stigma and raise awareness about suicide and suicide prevention; connect with people you know impacted by suicide, raise awareness, and share resources to help those at risk.

Learn more about our research

Virtual Workshop: Sleep, Circadian Rhythms and Mental Health
From our partners at Penn Medicine:

Virtual Workshop: Sleep, Circadian Rhythms and Mental Health

A two-day virtual workshop hosted by the University of Pennsylvania on November 4th & 5th, 11am-5pm ET.

Sleep and circadian rhythms are frequently disrupted in mental health disorders, and play vital roles in overall health and well-being, but mental health providers frequently do not receive exposure to these topics in their education.

The workshop is designed for mental health providers across multiple disciplines (e.g., nurses, psychologists, social workers, mental health specialists) who are interested in learning about the basic role that sleep and circadian rhythms play in the mental health and well-being of their clients. This workshop is intended for providers who have had very little exposure to sleep and circadian science.

Learn More

Cohen Veterans Bioscience team members will be presenting at the following upcoming conferences:

TBI Conference

TBI Conference

October 4-6, 2021

Pathways to Effective Treatments for Traumatic Brain Injury: 
A Roadmap towards Precision Solutions

Wednesday, October 6th from 12pm to 1pm ET

Moderator: Dr. Magali Haas (CVB CEO & President)
Panelists: Dr. Lisa Brenner, Dr. Allyson Gage (CVB Chief Medical Officer), Dr. Juliet Haarbauer-Krupa, Dr. Angela Lumba-Brown, Dr. Eric Prager (CVB Associate Director, External Affairs), Dr. Doug Smith, Dr. Elisabeth Anne Wilde


ECNP Congress

October 2-5, 2021

Dr. Chantelle Ferland-Beckham (CVB Director, Policy & Advocacy) will be presenting at this event.


2021 World Congress of Psychiatric Genetics

October 12-14, 2021

Dr. Andreas Jeromin (CVB Chief Scientific Officer) will be presenting at this event.


IEEE Engineering in Medicine & Biology Society (EMBC)

November 1-4, 2021

Dr. Roozbeh Atri (CVB Senior Data Scientist) will be presenting at this event.

Support Our Mission


Brain trauma can impact anyone.

We're working to advance brain health for
military service members, Veterans, and all people.

Together, we have the potential to help accelerate research and improve lives.
Donate to Cohen Veterans Bioscience
Donate Today
Follow Cohen Veterans Bioscience on Facebook
Follow Cohen Veterans Bioscience on Twitter
Follow Cohen Veterans Bioscience on LinkedIn
Follow Cohen Veterans Bioscience on Instagram
Follow Cohen Veterans Bioscience on YouTube
Copyright © 2021 Cohen Veterans Bioscience Inc., All rights reserved.


Want to change how you receive these emails?
You can update your preferences or unsubscribe from this list.