September 24, 2025
PLOS Biology
Ending publication bias: A values-based approach to surface null and negative results
Publication
Sex differences in traumatic stress reactivity in rats with and without a history of alcohol drinking
Citation:
Biology of Sex Differences 2020; 11: 27. https://doi.org/10.1186/s13293-020-00303-w
Biology of Sex Differences 2020; 11: 27. https://doi.org/10.1186/s13293-020-00303-w
Authored By:
Albrechet-Souza, L., Schratz, C.L. & Gilpin, N.W.
Albrechet-Souza, L., Schratz, C.L. & Gilpin, N.W.
Abstract:
Alcohol misuse and post-traumatic stress disorder (PTSD) are highly comorbid, and treatment outcomes are worse in individuals with both conditions. Although more men report experiencing traumatic events than women, the lifetime prevalence of PTSD is twice as high in females. Despite these data trends in humans, preclinical studies of traumatic stress reactivity have been performed almost exclusively in male animals.
Alcohol misuse and post-traumatic stress disorder (PTSD) are highly comorbid, and treatment outcomes are worse in individuals with both conditions. Although more men report experiencing traumatic events than women, the lifetime prevalence of PTSD is twice as high in females. Despite these data trends in humans, preclinical studies of traumatic stress reactivity have been performed almost exclusively in male animals.
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