Newsletter SignupSearch


The Neurobiology of Fear Generalization

Frontiers in Behavioral Neuroscience. 2018; 12: 329. Published online 2019 Jan 15. doi: 10.3389/fnbeh.2018.00329 PMID: 30697153
Authored By:
Arun Asok, Eric R. Kandel, Joseph B. Rayman
The generalization of fear memories is an adaptive neurobiological process that promotes survival in complex and dynamic environments. When confronted with a potential threat, an animal must select an appropriate defensive response based on previous experiences that are not identical, weighing cues and contextual information that may predict safety or danger. Like other aspects of fear memory, generalization is mediated by the coordinated actions of prefrontal, hippocampal, amygdalar, and thalamic brain areas. In this review article, we describe the current understanding of the behavioral, neural, genetic, and biochemical mechanisms involved in the generalization of fear. Fear generalization is a hallmark of many anxiety and stress-related disorders, and its emergence, severity, and manifestation are sex-dependent. Therefore, to improve the dialog between human and animal studies as well as to accelerate the development of effective therapeutics, we emphasize the need to examine both sex differences and remote timescales in rodent models.
Published in:
Frontiers in Behavioral Neuroscience

More Publications

September 9, 2022


Deep Learning for Daily Monitoring of Parkinson’s Disease Outside the Clinic Using Wearable Sensors

June 1, 2022

JAMA Network Open

Association of Posttraumatic Stress Disorder With Accelerated Cognitive Decline in Middle-aged Women

March 23, 2022

Journal of Neurotrauma

A Framework to Advance Biomarker Development in the Diagnosis, Outcome Prediction, and Treatment of Traumatic Brain Injury

February 26, 2022

Translational Psychiatry

Plasma biomarkers associated with deployment trauma and its consequences in post-9/11 era veterans: initial findings from the TRACTS longitudinal cohort

January 31, 2022

Biological Psychiatry

Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder

December 1, 2021

Neurotrauma Reports

Neurotrauma Reports Special Collection: Null Hypothesis Initiative

Cohen Veterans Bioscience - Advancing Brain Health

Get the latest updates in TBI and PTSD research

Sign up for our newsletter to learn how we’re advancing solutions for brain trauma.

This field is for validation purposes and should be left unchanged.