SOBP Training Workshop: “Enhancing the Utility of Preclinical Animal Models for Advancing CNS Therapeutics”

SOBP 2022

SOBP Training Workshop:

“Enhancing the Utility of Preclinical Animal Models for Advancing CNS Therapeutics”

April 27, 2022  –  8:00am – 5:00 pm  –   New Orleans, LA

Workshop Summary

Brain disorders are highly prevalent and substantially contribute to the overall global disease of burden.  Over the past 10-15 years, hundreds of compounds have been advanced into clinical testing based, in part, on evidence from preclinical data.  However, the vast majority of these compounds were later abandoned due to a lack of clinical efficacy.  While there are multiple reasons for clinical failure, one of the most frequently cited is the translational validity and overall quality of the preclinical data used as the basis for clinical research.  However, despite awareness and numerous efforts by publishers, funders, academic institutions, individual labs and other stakeholders to address the root causes, irreproducible research remains a challenge to R&D decision-making and limits the potential to speed new diagnostics and therapeutics for many brain disorders.

This workshop is aimed to early career researchers who seek training in the adoption and implementation of known tools to mitigate the causes of irreproducible research and thus enhance the translational relevance of preclinical research for clinical R&D.  Topics include good research practices,  strategies for effective experimental design, stringent statistical analyses, and transparent reporting and implementing a quality system in your laboratory. Further, to improve bi-directional awareness of the importance of preclinical research for R&D decision-making, this workshop will uniquely focus on the contribution of preclinical research to the drug development process and how all researchers can increase the likelihood of translational success by implementing good research practices. 

Workshop Objectives

  1. Understand how the pharmaceutical industry utilizes preclinical data to inform drug development. 
  2. Discuss key issues that contribute to poor rigor and reproducibility in preclinical research
  3. Introduce methods and tools that can maximize bidirectional translation between basic and clinical research. 

Agenda

TimeTopic

Style

Presenter
7:00 – 8:00 amArrivals and BreakfastAll
8:00 – 8:15 amWelcome & AgendaChantelle Ferland-Beckham, PhD
Senior Director, External Affairs
Cohen Veterans Bioscience
8:15 – 8:45 amHow does Preclinical Research Contribute to R&D Decision Making?KeynoteAllyson Gage, PhD
Chief Medical Officer
Cohen Veterans Bioscience
8:45 – 9:30 amHidden Obstacles in Study DesignLectureMartin C. Michel, PhD
Partnership for Assessment and Accreditation of Scientific Practice (PAASP)
9:30-10:00 amThe Importance of Sex as a Biological Variable for Research TranslationLectureJill Daniel, PhD
Professor Department of Psychology,
Director Tulane Brain Institute,
Tulane University
10:00 – 10:30 am

BREAK

10:30 – 11:00 amDeveloping a Statistical Analysis Plan BEFORE Experimental ConductLectureLee Lancashire, PhD
Chief Information Officer
Cohen Veterans Bioscience
11:00 – 11:30 amIntentional Data Collection: The Role of Preclinical CDEs and their Benefits for PsychiatryLectureMichelle C. LaPlaca, PhD
Professor, Department of Biomedical Engineering
Georgia Institute of Technology & Emory University
11:30 – 12:00 pmLearning from the Past: Search Strategies and Tools to Aid Study DesignLectureNikolaos Kokras, MD, PhD
Psychiatrist/Clinical Research Associate, Departments of Pharmacology & Psychiatry, University of Athens, Greece
12:00 – 1:00 pmLUNCH
1:00 – 1:30 pmCase Study: SPSLectureChantelle Ferland-Beckham, PhD
Senior Director, External Affairs
Cohen Veterans Bioscience
1:30 – 2:00 pmThe Importance of Pre-registration for ReplicationLectureTim Errington, PhD

Senior Director of Research, Center for Open Science

2:00 – 2:30 pmARRIVE Guidelines & Other ChecklistsLecturePenny Reynolds, PhD
Assistant Professor of Anesthesiology
University of Florida College of Medicine
2:30 – 3:00 pmBREAK
3:00 – 3:30 pmThe Unique Challenges of Achieving Translation in Psychiatry (focusing on animal models)KeynoteMagali Haas, MD, PhD
CEO & President,
Cohen Veterans Bioscience
3:30 – 4:15 pmKnowledge Management: The Role of QMS in Rigorous ResearchLectureMalcolm Macleod, PhD
GoEQIPD Guarantor
Professor of Neurology and Translational Neuroscience
Academic Lead for Research Improvement and Research Integrity
University of Edinburgh
4:15 – 4:45 pmTranslating Evidence into PolicyLectureMarc Avey, PhD
Director of Standards
Canadian Council on Animal Care
4:45-5:00 pmCLOSING COMMENTS & ADJOURNChantelle Ferland-Beckham, PhD
Senior Director, External Affairs
Cohen Veterans Bioscience
5:30 pmEVENING SOCIAL (Cocktails & Hors d’oeuvres)All

Speakers

Marc Avey, PhD

Marc Avey, PhD
Director of Standards, Canadian Council on Animal Care

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Jill Daniels, PhD

Jill Daniel, PhD
Professor of Psychology and Neuroscience, Tulane University

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Tim Errington, PhD

Tim Errington, PhD
Senior Director of Research, Center for Open Science

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Chantelle Ferland-Beckham, PhD

Chantelle Ferland-Beckham, PhD
Senior Director, External Affairs, Cohen Veterans Bioscience

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Allyson Gage, PhD

Allyson Gage, PhD
Chief Medical Officer, Cohen Veterans Bioscience

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Magali Haas, MD, PhD

Magali Haas, MD, PhD
CEO & President, Cohen Veterans Bioscience

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Nikolaos Kokras, MD

Nikolaos Kokras, MD, PhD
Psychiatrist & Research Associate, National and Kapodistrian University of Athens

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Lee Lancashire, PhD

Lee Lancashire, PhD
Chief Information Officer, Cohen Veterans Bioscience

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Michelle LaPlaca, PhD

Michelle C. LaPlaca, PhD
Professor, Georgia Tech and Emory University

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Malcom Macleod, PhD

Malcom Macleod, PhD
Professor of Neurology & Translational Neurosciences and Academic Lead for Research Improvement and Research Integrity, University of Edinburgh

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Martin C. Michel

Martin Michel, MD
Professor of Pharmacology, Johannes Gutenberg University Mainz

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Penny Reynolds, PhD

Penny Reynolds, PhD
Research Applied Statistician, University of Florida

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