Establishing a Normative Neuroimaging Library to Support Traumatic Brain Injury Diagnosis and Management

About James R. Stone, MD, PhD
Associate Professor and Vice Chair of Research in the Department of Radiology and Medical Imaging
University of Virginia

James R. Stone, MD, PhD is Associate Professor and Vice Chair of Research in the Department of Radiology and Medical Imaging at the University of Virginia. He is also a founding member of the American College of Radiology Head Injury Institute. He is a clinical Interventional Radiologist with a neuroscience background. His laboratory currently explores questions related to improving the clinical diagnosis of traumatic brain injury (TBI) in both preclinical models and human subjects.

Ongoing preclinical work includes the design and investigation of molecular imaging probes for the detection of acute and chronic effects of TBI. Probes under investigation include those targeting inflammation, cell death, and altered neurotransmitter receptor activity. He is involved with work exploring neurovascular changes in a preclinical blast TBI model. Human subjects efforts focus upon exploring neuroimaging correlates of repetitive low-level blast exposure in military populations. The goals of this work include determining whether military service members in this environment are at risk for development of mild TBI and helping to establish safe stand off limits for low-level blast exposure.

Additionally, Dr. Stone is involved with efforts to build a normative library to support improved population level research and work towards single subject assessment of patients with TBI. He is additionally involved with work utilizing machine learning/deep learning approaches for the automated segmentation of imaging findings diagnostic of TBI. Further, he is a member of the neuroimaging core laboratory for the Chronic Effects of Neurotrauma Consortium. Dr. Stone’s work receives support from the Defense Health Program through USUHS and MRMC. His work also receives support from the Office of Naval Research and the Department of Veterans Affairs. His participation on efforts to establish a normative neuroimaging library receives support from Cohen Veterans Bioscience.